BDBM133784 US8846699, 102

SMILES: CN1CCN(CC(=O)NCCOc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1

InChI Key: InChIKey=BVCQMVAUBMWNAI-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 133784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM133784 (US8846699, 102) Show SMILES CN1CCN(CC(=O)NCCOc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1 Show InChI InChI=1S/C26H29BrFN7O3/c1-3-24(36)32-22-13-18-21(30-16-31-26(18)33-20-5-4-17(27)12-19(20)28)14-23(22)38-11-6-29-25(37)15-35-9-7-34(2)8-10-35/h3-5,12-14,16H,1,6-11,15H2,2H3,(H,29,37)(H,32,36)(H,30,31,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	25
Hanmi Pharm. Co., Ltd. US Patent					Assay Description EGFR1 (HER-1) enzyme assay was carried out by using Tyrosine Kinase Assay Kit Green. The entire assay was conducted in accordance with EGFR PTK inhib...				US Patent US8846699 (2014) BindingDB Entry DOI: 10.7270/Q2KW5DRK
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM133784 (US8846699, 102) Show SMILES CN1CCN(CC(=O)NCCOc2cc3ncnc(Nc4ccc(Br)cc4F)c3cc2NC(=O)C=C)CC1 Show InChI InChI=1S/C26H29BrFN7O3/c1-3-24(36)32-22-13-18-21(30-16-31-26(18)33-20-5-4-17(27)12-19(20)28)14-23(22)38-11-6-29-25(37)15-35-9-7-34(2)8-10-35/h3-5,12-14,16H,1,6-11,15H2,2H3,(H,29,37)(H,32,36)(H,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	654	n/a	n/a	n/a	n/a	7.4	25
Hanmi Pharm. Co., Ltd. US Patent					Assay Description VEGFR2 (KDR, Proquinase) enzyme assay (auto-phosphorylation assay) was carried out by using Tyrosine Kinase Assay Kit Green (Panvera). The entire ass...				US Patent US8846699 (2014) BindingDB Entry DOI: 10.7270/Q2KW5DRK
					More data for this Ligand-Target Pair