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SMILES: CCC[C@@H](NC(=O)N1C\C(=N\OC)N(C)CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1

InChI Key: InChIKey=IPUGCSWYOLAVOE-LJVDJLKTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 134264   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Chymase


(Homo sapiens (Human))		BDBM134264
PNG
(US8846660, 34)
Show SMILES CCC[C@@H](NC(=O)N1C\C(=N\OC)N(C)CC(Cc2cc(Cl)ccc2OC)C1=O)c1ccc(C(O)=O)c(N)c1 |r|
Show InChI InChI=1S/C27H34ClN5O6/c1-5-6-22(16-7-9-20(26(35)36)21(29)13-16)30-27(37)33-15-24(31-39-4)32(2)14-18(25(33)34)11-17-12-19(28)8-10-23(17)38-3/h7-10,12-13,18,22H,5-6,11,14-15,29H2,1-4H3,(H,30,37)(H,35,36)/b31-24-/t18?,22-/m1/s1
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Similars
US Patent
n/an/a 30n/an/an/an/a7.525



Daiichi Sankyo Company, Ltd.

US Patent


Assay Description
The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...

US Patent US8846660 (2014)


BindingDB Entry DOI: 10.7270/Q22V2DTB
More data for this
Ligand-Target Pair