BDBM13431 CHEMBL204336::N-{4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(methylcarbamoyl)ethyl]phenyl}sulfamic acid::phenylalanine analog 2::sulfamic acid deriv. 2
SMILES: CNC(=O)[C@H](Cc1ccc(NS(O)(=O)=O)cc1)NC(=O)OC(C)(C)C
InChI Key: InChIKey=SQRHYYPEUFLSML-LBPRGKRZSA-N
Data: 2 IC50
PDB links: 1 PDB ID contains this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM13431 (CHEMBL204336 | N-{4-[(2S)-2-{[(tert-butoxy)carbony...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 3.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter & Gamble Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of PTP1B | Bioorg Med Chem Lett 16: 4252-6 (2006) Article DOI: 10.1016/j.bmcl.2006.05.074 BindingDB Entry DOI: 10.7270/Q2D50MK4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-Tyrosine Phosphatase 1B (PTP1B) (Homo sapiens (Human)) | BDBM13431 (CHEMBL204336 | N-{4-[(2S)-2-{[(tert-butoxy)carbony...) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 3.96E+4 | n/a | n/a | n/a | n/a | 7.0 | 22 |
Procter & Gamble Pharmaceuticals | Assay Description The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic... | Bioorg Med Chem Lett 16: 1574-8 (2006) Article DOI: 10.1016/j.bmcl.2005.12.051 BindingDB Entry DOI: 10.7270/Q2PN93WP | |||||||||||
More data for this Ligand-Target Pair |