BDBM1355 (9bR)-9b-phenyl-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol-5-one::(R)-9b-Phenyl-2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-one::Thiazoloisoindol-5-one deriv. 1R

SMILES: O=C1N2CCS[C@@]2(c2ccccc12)c1ccccc1

InChI Key: InChIKey=CTGFADZNCCTVMP-MRXNPFEDSA-N

Data: 1 IC50

PDB links: 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1355 ((9bR)-9b-phenyl-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]...) Show SMILES O=C1N2CCS[C@@]2(c2ccccc12)c1ccccc1 |r| Show InChI InChI=1S/C16H13NOS/c18-15-13-8-4-5-9-14(13)16(17(15)10-11-19-16)12-6-2-1-3-7-12/h1-9H,10-11H2/t16-/m1/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	7.7	37
Boehringer Mannheim GmbH					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 36: 2526-35 (1993) Article DOI: 10.1021/jm00069a011 BindingDB Entry DOI: 10.7270/Q2BR8QCZ
					More data for this Ligand-Target Pair				3D Structure (docked)