BDBM135777 US10179804, Example 162::US10632171, Peptide No. 162::US8846601, 162::US9458201, 162

SMILES: CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O

InChI Key: InChIKey=KOMGNGDDTPNSKC-PDBPWWFNSA-N

Data: 8 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 135777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US10632171 (2020)
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	-11.8	n/a	n/a	n/a	n/a	n/a	7.5	37
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US9458201 (2016) BindingDB Entry DOI: 10.7270/Q2HT2N79
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US8846601 (2014) BindingDB Entry DOI: 10.7270/Q2SF2TWK
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Palatin Technologies, Inc. US Patent					Assay Description Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...				US Patent US10179804 (2019) BindingDB Entry DOI: 10.7270/Q24T6MFP
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US10632171 (2020)
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	255	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US8846601 (2014) BindingDB Entry DOI: 10.7270/Q2SF2TWK
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	255	-9.35	n/a	n/a	n/a	n/a	n/a	7.5	37
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US9458201 (2016) BindingDB Entry DOI: 10.7270/Q2HT2N79
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor 1 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	255	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Palatin Technologies, Inc. US Patent					Assay Description A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...				US Patent US10632171 (2020)
					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	22	n/a	n/a	7.5	37
Palatin Technologies, Inc. US Patent					Assay Description Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...				US Patent US9458201 (2016) BindingDB Entry DOI: 10.7270/Q2HT2N79
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM135777 (US10179804, Example 162 | US10632171, Peptide No. ...) Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O |r| Show InChI InChI=1S/C50H70N16O10/c1-28(67)60-33(16-9-21-58-49(53)54)43(71)61-34-15-7-8-20-57-41(69)27-36(42(52)70)63-47(75)38(25-30-18-19-31-13-5-6-14-32(31)23-30)64-45(73)35(17-10-22-59-50(55)56)62-46(74)37(24-29-11-3-2-4-12-29)65-48(76)39(26-40(51)68)66-44(34)72/h2-6,11-14,18-19,23,33-39H,7-10,15-17,20-22,24-27H2,1H3,(H2,51,68)(H2,52,70)(H,57,69)(H,60,67)(H,61,71)(H,62,74)(H,63,75)(H,64,73)(H,65,76)(H,66,72)(H4,53,54,58)(H4,55,56,59)/t33-,34-,35-,36-,37+,38-,39-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	0.850	n/a	n/a	7.5	37
Palatin Technologies, Inc. US Patent					Assay Description Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...				US Patent US9458201 (2016) BindingDB Entry DOI: 10.7270/Q2HT2N79
					More data for this Ligand-Target Pair