null

SMILES: COCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1=CCCC1

InChI Key: InChIKey=GANCFFDZYNZRLX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 136103   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM136103 (US8853203, 120 | US9650377, Example 120) Show SMILES COCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1=CCCC1 |c:25,t:9,28| Show InChI InChI=1S/C23H24N4O2/c1-29-14-17-13-26(15-25-17)22-11-21-20-8-4-7-18(16-5-2-3-6-16)19(20)9-10-27(21)23(28)12-24-22/h4-5,7-8,11,13,15H,2-3,6,9-10,12,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...				US Patent US8853203 (2014) BindingDB Entry DOI: 10.7270/Q2MP520T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM136103 (US8853203, 120 | US9650377, Example 120) Show SMILES COCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1=CCCC1 |c:25,t:9,28| Show InChI InChI=1S/C23H24N4O2/c1-29-14-17-13-26(15-25-17)22-11-21-20-8-4-7-18(16-5-2-3-6-16)19(20)9-10-27(21)23(28)12-24-22/h4-5,7-8,11,13,15H,2-3,6,9-10,12,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...				US Patent US9650377 (2017) BindingDB Entry DOI: 10.7270/Q2G73GT2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM136103 (US8853203, 120 | US9650377, Example 120) Show SMILES COCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1=CCCC1 |c:25,t:9,28| Show InChI InChI=1S/C23H24N4O2/c1-29-14-17-13-26(15-25-17)22-11-21-20-8-4-7-18(16-5-2-3-6-16)19(20)9-10-27(21)23(28)12-24-22/h4-5,7-8,11,13,15H,2-3,6,9-10,12,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...				US Patent US9650377 (2017) BindingDB Entry DOI: 10.7270/Q2G73GT2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM136103 (US8853203, 120 | US9650377, Example 120) Show SMILES COCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1=CCCC1 |c:25,t:9,28| Show InChI InChI=1S/C23H24N4O2/c1-29-14-17-13-26(15-25-17)22-11-21-20-8-4-7-18(16-5-2-3-6-16)19(20)9-10-27(21)23(28)12-24-22/h4-5,7-8,11,13,15H,2-3,6,9-10,12,14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...				US Patent US8853203 (2014) BindingDB Entry DOI: 10.7270/Q2MP520T
					More data for this Ligand-Target Pair