BDBM1362 9b-(anthracen-9-yl)-2H,3H,5H,9bH-isoindolo[1,2-b][1,3]thiazol-5-one::Thiazoloisoindol-5-one deriv. 7

SMILES: O=C1N2CCSC2(c2ccccc12)c1c2ccccc2cc2ccccc12

InChI Key: InChIKey=SLZIXYGPYFYCPU-UHFFFAOYSA-N

Data: 1 IC50

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1362 (9b-(anthracen-9-yl)-2H,3H,5H,9bH-isoindolo[1,2-b][...) Show SMILES O=C1N2CCSC2(c2ccccc12)c1c2ccccc2cc2ccccc12 Show InChI InChI=1S/C24H17NOS/c26-23-20-11-5-6-12-21(20)24(25(23)13-14-27-24)22-18-9-3-1-7-16(18)15-17-8-2-4-10-19(17)22/h1-12,15H,13-14H2	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	7.7	37
Boehringer Mannheim GmbH					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 36: 2526-35 (1993) Article DOI: 10.1021/jm00069a011 BindingDB Entry DOI: 10.7270/Q2BR8QCZ
					More data for this Ligand-Target Pair