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SMILES: C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CCCO)COC2=O)C(=O)NC(=O)NC1=O

InChI Key: InChIKey=RUGGKUCTSZCYFB-KACXOKKCSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 139399   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA gyrase subunit A


(Escherichia coli (strain K12))		BDBM139399
PNG
(US8889671, 29)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CCCO)COC2=O)C(=O)NC(=O)NC1=O |r|
Show InChI InChI=1S/C24H26FN5O8/c1-10-8-29-16-12(7-24(18(29)11(2)37-10)20(32)26-22(34)27-21(24)33)6-14-17(15(16)25)38-28-19(14)30-13(4-3-5-31)9-36-23(30)35/h6,10-11,13,18,31H,3-5,7-9H2,1-2H3,(H2,26,27,32,33,34)/t10-,11+,13+,18-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
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Similars
US Patent
n/an/a 270n/an/an/an/a7.5n/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...

US Patent US8889671 (2014)


BindingDB Entry DOI: 10.7270/Q22J69JX
More data for this
Ligand-Target Pair