Found 3 hits for monomerid = 14000 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14000
((6R)-23-chloro-27-oxo-20-oxa-3,7,11,13-tetraazapen...)Show SMILES Clc1cc2CN3CC[C@@H](NCc4cncn4Cc4ccc(C#N)c(Oc(c1)c2)c4)C3=O |r| Show InChI InChI=1S/C23H20ClN5O2/c24-18-5-16-6-20(8-18)31-22-7-15(1-2-17(22)9-25)12-29-14-26-10-19(29)11-27-21-3-4-28(13-16)23(21)30/h1-2,5-8,10,14,21,27H,3-4,11-13H2/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Merck Research Laboratories
| Assay Description
Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin... |
J Med Chem 45: 2388-409 (2002)
Article DOI: 10.1021/jm010531d
BindingDB Entry DOI: 10.7270/Q2T72FPK |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM14000
((6R)-23-chloro-27-oxo-20-oxa-3,7,11,13-tetraazapen...)Show SMILES Clc1cc2CN3CC[C@@H](NCc4cncn4Cc4ccc(C#N)c(Oc(c1)c2)c4)C3=O |r| Show InChI InChI=1S/C23H20ClN5O2/c24-18-5-16-6-20(8-18)31-22-7-15(1-2-17(22)9-25)12-29-14-26-10-19(29)11-27-21-3-4-28(13-16)23(21)30/h1-2,5-8,10,14,21,27H,3-4,11-13H2/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human ERG channel |
J Med Chem 52: 4266-76 (2009)
Article DOI: 10.1021/jm900002x
BindingDB Entry DOI: 10.7270/Q2MK6DT2 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta [A2V]/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14000
((6R)-23-chloro-27-oxo-20-oxa-3,7,11,13-tetraazapen...)Show SMILES Clc1cc2CN3CC[C@@H](NCc4cncn4Cc4ccc(C#N)c(Oc(c1)c2)c4)C3=O |r| Show InChI InChI=1S/C23H20ClN5O2/c24-18-5-16-6-20(8-18)31-22-7-15(1-2-17(22)9-25)12-29-14-26-10-19(29)11-27-21-3-4-28(13-16)23(21)30/h1-2,5-8,10,14,21,27H,3-4,11-13H2/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
| Assay Description
The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit... |
J Med Chem 45: 2388-409 (2002)
Article DOI: 10.1021/jm010531d
BindingDB Entry DOI: 10.7270/Q2T72FPK |
More data for this
Ligand-Target Pair | |
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