BDBM140141 US8901315, 274

SMILES: Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCS1(=O)=O

InChI Key: InChIKey=NSNPLHLWMMBOPL-QAQDUYKDSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140141   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 4 (PDE4) (Mus musculus (Mouse))	BDBM140141 (US8901315, 274) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCS1(=O)=O |r,wU:18.20,wD:21.27,(-6.96,4.1,;-6.19,2.77,;-7.1,1.52,;-6.19,.27,;-6.59,-1.21,;-8.08,-1.61,;-8.48,-3.1,;-7.39,-4.19,;-5.9,-3.79,;-5.5,-2.3,;-4.73,.75,;-3.27,.27,;-2.36,1.52,;-3.27,2.77,;-4.73,2.29,;-.82,1.52,;-.05,.19,;-.05,2.85,;1.49,2.85,;2.26,4.19,;3.8,4.19,;4.57,2.85,;3.8,1.52,;2.26,1.52,;6.11,2.85,;7.01,4.1,;8.48,3.62,;8.48,2.08,;7.01,1.61,;6.24,.27,;7.78,.27,)| Show InChI InChI=1S/C22H32N4O3S2/c1-15-19-14-20(30-22(19)26(24-15)18-6-3-2-4-7-18)21(27)23-16-8-10-17(11-9-16)25-12-5-13-31(25,28)29/h14,16-18H,2-13H2,1H3,(H,23,27)/t16-,17-	PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	6.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 4 (phosphodiesterase IV) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifie...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair
Phosphodiesterase 7 (Homo sapiens (Human))	BDBM140141 (US8901315, 274) Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCS1(=O)=O |r,wU:18.20,wD:21.27,(-6.96,4.1,;-6.19,2.77,;-7.1,1.52,;-6.19,.27,;-6.59,-1.21,;-8.08,-1.61,;-8.48,-3.1,;-7.39,-4.19,;-5.9,-3.79,;-5.5,-2.3,;-4.73,.75,;-3.27,.27,;-2.36,1.52,;-3.27,2.77,;-4.73,2.29,;-.82,1.52,;-.05,.19,;-.05,2.85,;1.49,2.85,;2.26,4.19,;3.8,4.19,;4.57,2.85,;3.8,1.52,;2.26,1.52,;6.11,2.85,;7.01,4.1,;8.48,3.62,;8.48,2.08,;7.01,1.61,;6.24,.27,;7.78,.27,)| Show InChI InChI=1S/C22H32N4O3S2/c1-15-19-14-20(30-22(19)26(24-15)18-6-3-2-4-7-18)21(27)23-16-8-10-17(11-9-16)25-12-5-13-31(25,28)29/h14,16-18H,2-13H2,1H3,(H,23,27)/t16-,17-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.90	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...				US Patent US8901315 (2014) BindingDB Entry DOI: 10.7270/Q2GM860P
					More data for this Ligand-Target Pair