BDBM140547 US8912221, 20

SMILES: C[C@@H](NC(=O)C1(COC1)NC(=O)c1cc(C)no1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1

InChI Key: InChIKey=YSYVCUNONCNAIK-GFCCVEGCSA-N

Data: 1 KI

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 140547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bradykinin B1 receptor (Homo sapiens (Human))	BDBM140547 (US8912221, 20) Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1cc(C)no1)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1 |r| Show InChI InChI=1S/C24H21ClF2N8O4/c1-11-4-18(39-33-11)22(36)30-24(9-38-10-24)23(37)29-12(2)20-17(27)5-13(8-28-20)15-6-14(25)7-16(26)19(15)21-31-34-35(3)32-21/h4-8,12H,9-10H2,1-3H3,(H,29,37)(H,30,36)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.60	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...				US Patent US8912221 (2014) BindingDB Entry DOI: 10.7270/Q2668BWC
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