BDBM141518 US8921373, 5::US9365563, 204::US9878991, Compound 204

SMILES: FC(F)(F)c1ccc(NC(=O)N2CCC(F)(CC2)c2ncccc2Cl)nc1

InChI Key: InChIKey=VWPACZUSCZWKKR-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 141518   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM141518 (US8921373, 5 | US9365563, 204 | US9878991, Compoun...) Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC(F)(CC2)c2ncccc2Cl)nc1 Show InChI InChI=1S/C17H15ClF4N4O/c18-12-2-1-7-23-14(12)16(19)5-8-26(9-6-16)15(27)25-13-4-3-11(10-24-13)17(20,21)22/h1-4,7,10H,5-6,8-9H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	154	n/a	n/a	n/a	n/a	7.4	n/a
Shionogi & Co., Ltd. US Patent					Assay Description Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...				US Patent US8921373 (2014) BindingDB Entry DOI: 10.7270/Q28051BW
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM141518 (US8921373, 5 | US9365563, 204 | US9878991, Compoun...) Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC(F)(CC2)c2ncccc2Cl)nc1 Show InChI InChI=1S/C17H15ClF4N4O/c18-12-2-1-7-23-14(12)16(19)5-8-26(9-6-16)15(27)25-13-4-3-11(10-24-13)17(20,21)22/h1-4,7,10H,5-6,8-9H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	167	n/a	n/a	n/a	n/a	7.4	n/a
Purdue Pharma L.P. US Patent					Assay Description Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...				US Patent US9365563 (2016) BindingDB Entry DOI: 10.7270/Q2P26X1D
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM141518 (US8921373, 5 | US9365563, 204 | US9878991, Compoun...) Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC(F)(CC2)c2ncccc2Cl)nc1 Show InChI InChI=1S/C17H15ClF4N4O/c18-12-2-1-7-23-14(12)16(19)5-8-26(9-6-16)15(27)25-13-4-3-11(10-24-13)17(20,21)22/h1-4,7,10H,5-6,8-9H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	154	n/a	n/a	n/a	n/a	7.4	n/a
Purdue Pharma L.P. US Patent					Assay Description Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...				US Patent US9878991 (2018) BindingDB Entry DOI: 10.7270/Q2TF00CG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM141518 (US8921373, 5 | US9365563, 204 | US9878991, Compoun...) Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC(F)(CC2)c2ncccc2Cl)nc1 Show InChI InChI=1S/C17H15ClF4N4O/c18-12-2-1-7-23-14(12)16(19)5-8-26(9-6-16)15(27)25-13-4-3-11(10-24-13)17(20,21)22/h1-4,7,10H,5-6,8-9H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	167	n/a	n/a	n/a	n/a	7.4	n/a
Purdue Pharma L.P. US Patent					Assay Description Two days prior to performing this assay, cells are seeded in poly-D-lysine-coated 96-well clear-bottom black plates (50,000 cells/well) in growth med...				US Patent US9878991 (2018) BindingDB Entry DOI: 10.7270/Q2TF00CG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM141518 (US8921373, 5 | US9365563, 204 | US9878991, Compoun...) Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC(F)(CC2)c2ncccc2Cl)nc1 Show InChI InChI=1S/C17H15ClF4N4O/c18-12-2-1-7-23-14(12)16(19)5-8-26(9-6-16)15(27)25-13-4-3-11(10-24-13)17(20,21)22/h1-4,7,10H,5-6,8-9H2,(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	154	n/a	n/a	n/a	n/a	7.4	n/a
Purdue Pharma L.P. US Patent					Assay Description Two days prior to performing this assay, cells are seeded on poly-D-lysine-coated 96-well clear-bottom black plates (commercially available from Bect...				US Patent US9365563 (2016) BindingDB Entry DOI: 10.7270/Q2P26X1D
					More data for this Ligand-Target Pair