BDBM142663 US8937068, 149

SMILES: CCNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1

InChI Key: InChIKey=SNKCWSSPDZFKAC-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142663   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM142663 (US8937068, 149) Show SMILES CCNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1 Show InChI InChI=1S/C16H15N5OS/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	954	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Jnk1 & Jnk2 (Homo sapiens (Human))	BDBM142663 (US8937068, 149) Show SMILES CCNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1 Show InChI InChI=1S/C16H15N5OS/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM142663 (US8937068, 149) Show SMILES CCNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1 Show InChI InChI=1S/C16H15N5OS/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM142663 (US8937068, 149) Show SMILES CCNC(=S)Nc1ccc2ncc(nc2n1)-c1ccc(O)cc1 Show InChI InChI=1S/C16H15N5OS/c1-2-17-16(23)21-14-8-7-12-15(20-14)19-13(9-18-12)10-3-5-11(22)6-4-10/h3-9,22H,2H2,1H3,(H2,17,19,20,21,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair