BDBM142690 US8937068, 183

SMILES: CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1

InChI Key: InChIKey=JADAOPXXHHTXCZ-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM142690 (US8937068, 183) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1 Show InChI InChI=1S/C24H23N5O5S/c1-4-25-24(30)29-22-12-10-18-23(28-22)27-19(14-26-18)16-7-11-20(21(13-16)33-3)34-35(31,32)17-8-5-15(2)6-9-17/h5-14H,4H2,1-3H3,(H2,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	203	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Jnk1 & Jnk2 (Homo sapiens (Human))	BDBM142690 (US8937068, 183) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1 Show InChI InChI=1S/C24H23N5O5S/c1-4-25-24(30)29-22-12-10-18-23(28-22)27-19(14-26-18)16-7-11-20(21(13-16)33-3)34-35(31,32)17-8-5-15(2)6-9-17/h5-14H,4H2,1-3H3,(H2,25,27,28,29,30)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM142690 (US8937068, 183) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1 Show InChI InChI=1S/C24H23N5O5S/c1-4-25-24(30)29-22-12-10-18-23(28-22)27-19(14-26-18)16-7-11-20(21(13-16)33-3)34-35(31,32)17-8-5-15(2)6-9-17/h5-14H,4H2,1-3H3,(H2,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM142690 (US8937068, 183) Show SMILES CCNC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(OS(=O)(=O)c2ccc(C)cc2)c(OC)c1 Show InChI InChI=1S/C24H23N5O5S/c1-4-25-24(30)29-22-12-10-18-23(28-22)27-19(14-26-18)16-7-11-20(21(13-16)33-3)34-35(31,32)17-8-5-15(2)6-9-17/h5-14H,4H2,1-3H3,(H2,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Zentaris GmbH US Patent					Assay Description The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...				US Patent US8937068 (2015) BindingDB Entry DOI: 10.7270/Q2H993WP
					More data for this Ligand-Target Pair