null

SMILES: OC[C@H]1C[C@@H]1Cn1cc(Nc2nccc(n2)-c2ccc(OCC3CCC3)c(c2)C#N)cn1

InChI Key: InChIKey=SMBITOOEILSWPI-WOJBJXKFSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 144158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human))	BDBM144158 (US8969335, A95) Show SMILES OC[C@H]1C[C@@H]1Cn1cc(Nc2nccc(n2)-c2ccc(OCC3CCC3)c(c2)C#N)cn1 |r| Show InChI InChI=1S/C24H26N6O2/c25-10-18-8-17(4-5-23(18)32-15-16-2-1-3-16)22-6-7-26-24(29-22)28-21-11-27-30(13-21)12-19-9-20(19)14-31/h4-8,11,13,16,19-20,31H,1-3,9,12,14-15H2,(H,26,28,29)/t19-,20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM144158 (US8969335, A95) Show SMILES OC[C@H]1C[C@@H]1Cn1cc(Nc2nccc(n2)-c2ccc(OCC3CCC3)c(c2)C#N)cn1 |r| Show InChI InChI=1S/C24H26N6O2/c25-10-18-8-17(4-5-23(18)32-15-16-2-1-3-16)22-6-7-26-24(29-22)28-21-11-27-30(13-21)12-19-9-20(19)14-31/h4-8,11,13,16,19-20,31H,1-3,9,12,14-15H2,(H,26,28,29)/t19-,20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	30
MERCK PATENT GmbH US Patent					Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla...				US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN
					More data for this Ligand-Target Pair