BDBM144165 US8969335, A102
SMILES: OCc1nccnc1Nc1cc(ccn1)-c1ccc(OC2CCOCC2)c(c1)C#N
InChI Key: InChIKey=NBXRQAXVXWKQJZ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human)) | BDBM144165 (US8969335, A102) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 430 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MERCK PATENT GmbH US Patent | Assay Description 1 nM IKKe, 800 nM biotinylated IkBalpha(19-42) peptide (Biotin-C6-C6-GLKKERLLDDRHDSGLDSMKDEE) and 10 μM ATP (spiked with 0.3 uCi of 33P-ATP/well) ar... | US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM144165 (US8969335, A102) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 350 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MERCK PATENT GmbH US Patent | Assay Description The kinase assay is performed as 384-well flashplate assay (for example for Topcount measurement).0.6 nM TANK binding kinase (TBK1), 800 nM biotinyla... | US Patent US8969335 (2015) BindingDB Entry DOI: 10.7270/Q25X27NN | |||||||||||
More data for this Ligand-Target Pair |