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SMILES: CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(OC)c2)nc1N[C@H]1CC[C@H](O)CC1

InChI Key: InChIKey=NLUFJOOZRRYLPY-SAABIXHNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144290   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor (Homo sapiens (Human))	BDBM144290 (US8969336, 355) Show SMILES CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(OC)c2)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:31.34,wD:28.30,(4.72,1.95,;4.72,.41,;3.38,-.36,;2,.38,;.67,-.38,;-.42,.7,;-.42,2.24,;-1.91,.31,;.67,-1.93,;-.67,-2.69,;-2,-1.93,;-2,-.38,;-3.33,.38,;-4.67,-.38,;-6,.38,;-6,1.93,;-7.34,2.69,;-8.72,1.95,;-10.05,2.72,;-8.67,.38,;-7.34,-.38,;-4.72,-1.95,;-6.05,-2.72,;-6.05,-4.26,;-3.33,-2.69,;2,-2.69,;3.33,-1.93,;4.67,-2.69,;6,-1.93,;7.34,-2.69,;8.67,-1.93,;8.67,-.38,;10,.38,;7.34,.38,;6,-.38,)| Show InChI InChI=1S/C25H37N7O3/c1-4-19-24(27-16-5-8-18(33)9-6-16)30-25(22(29-19)23(26)34)28-17-7-10-20(21(15-17)35-3)32-13-11-31(2)12-14-32/h7,10,15-16,18,33H,4-6,8-9,11-14H2,1-3H3,(H2,26,34)(H2,27,28,30)/t16-,18-	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent					Assay Description A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,...				US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW
					More data for this Ligand-Target Pair