BDBM14464 (-)-4-(3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(S)-yl)-4-(4-pyridinylacetyl)-piperazine N4-Oxide::4-(2-{4-[(2S)-6-bromo-13,15-dichloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperazin-1-yl}-2-oxoethyl)-1-oxidopyridin-1-ium::Trihalobenzocycloheptapyridine Tricyclic Compound 36
SMILES: [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Cl)c23)cc1
InChI Key: InChIKey=TVUZXHJCUAQECC-VWLOTQADSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Protein Farnesyltransferase (PFT) (Homo sapiens (Human)) | BDBM14464![]() ((-)-4-(3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >110 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute | Assay Description FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... | J Med Chem 41: 4890-902 (1998) Article DOI: 10.1021/jm980462b BindingDB Entry DOI: 10.7270/Q2ZS2TRS | |||||||||||
More data for this Ligand-Target Pair |