BDBM145531 US8952169, 327

SMILES: Fc1cc(OCC2(CCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1

InChI Key: InChIKey=QUYXMONBUXYAKT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145531   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145531 (US8952169, 327) Show SMILES Fc1cc(OCC2(CCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C19H21F4NO4S/c20-15-9-16(28-10-18(6-1-7-18)19(21,22)23)13(11-2-3-11)8-14(15)17(25)24-29(26,27)12-4-5-12/h8-9,11-12H,1-7,10H2,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145531 (US8952169, 327) Show SMILES Fc1cc(OCC2(CCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 Show InChI InChI=1S/C19H21F4NO4S/c20-15-9-16(28-10-18(6-1-7-18)19(21,22)23)13(11-2-3-11)8-14(15)17(25)24-29(26,27)12-4-5-12/h8-9,11-12H,1-7,10H2,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair