BDBM146676 US8957073, 4.10::US9718803, 4.10

SMILES: C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cccnc1

InChI Key: InChIKey=NCCZRGLAOHWLIZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 146676   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM146676 (US8957073, 4.10 | US9718803, 4.10) Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cccnc1 Show InChI InChI=1S/C21H17N5/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00800	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...				US Patent US9718803 (2017) BindingDB Entry DOI: 10.7270/Q2J968DN
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM146676 (US8957073, 4.10 | US9718803, 4.10) Show SMILES C1C(CN1c1ccc2ccccc2n1)c1nccnc1-c1cccnc1 Show InChI InChI=1S/C21H17N5/c1-2-6-18-15(4-1)7-8-19(25-18)26-13-17(14-26)21-20(23-10-11-24-21)16-5-3-9-22-12-16/h1-12,17H,13-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00787	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...				US Patent US8957073 (2015) BindingDB Entry DOI: 10.7270/Q2PR7TPZ
					More data for this Ligand-Target Pair