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SMILES: NC1=N[C@]2(CO[C@H](CC2CS1)c1nnco1)c1ccc(F)cc1F

InChI Key: InChIKey=VBXCGICXNVLUFX-HHWPCOLFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 148184   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))		BDBM148184
PNG
(US8962616, 14)
Show SMILES NC1=N[C@]2(CO[C@H](CC2CS1)c1nnco1)c1ccc(F)cc1F |t:1|
Show InChI InChI=1S/C15H14F2N4O2S/c16-9-1-2-10(11(17)4-9)15-6-22-12(13-21-19-7-23-13)3-8(15)5-24-14(18)20-15/h1-2,4,7-8,12H,3,5-6H2,(H2,18,20)/t8?,12-,15+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
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Similars
US Patent
n/an/a 2.21E+3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...

US Patent US8962616 (2015)


BindingDB Entry DOI: 10.7270/Q20Z7216
More data for this
Ligand-Target Pair