BDBM148199 US8962630, 8

SMILES: CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCCNCC3)nc2n1C1CCCC1

InChI Key: InChIKey=GXSHOVGORXNAQT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148199   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM148199 (US8962630, 8) Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCCNCC3)nc2n1C1CCCC1 Show InChI InChI=1S/C24H32N8O/c1-30(2)23(33)20-14-17-15-27-24(29-22(17)32(20)18-6-3-4-7-18)28-21-9-8-19(16-26-21)31-12-5-10-25-11-13-31/h8-9,14-16,18,25H,3-7,10-13H2,1-2H3,(H,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The assay was run under the conditions identical to that for CDK1/cyclin B except 0.25 nM CDK1/cyclin B was replaced with 0.3 nM CDK2/cyclin A. A 384...				US Patent US8962630 (2015) BindingDB Entry DOI: 10.7270/Q2RJ4H6C
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM148199 (US8962630, 8) Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCCNCC3)nc2n1C1CCCC1 Show InChI InChI=1S/C24H32N8O/c1-30(2)23(33)20-14-17-15-27-24(29-22(17)32(20)18-6-3-4-7-18)28-21-9-8-19(16-26-21)31-12-5-10-25-11-13-31/h8-9,14-16,18,25H,3-7,10-13H2,1-2H3,(H,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description A 384-well microtiter IMAP-FPT (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The ...				US Patent US8962630 (2015) BindingDB Entry DOI: 10.7270/Q2RJ4H6C
					More data for this Ligand-Target Pair