null
SMILES: CN1CCN(Cc2cccc(Nc3ncc4CN(CCc4n3)c3cc(NC(=O)c4cccc(c4)C(F)(F)F)ccc3C)c2)CC1
InChI Key: InChIKey=HJRJXYSRPDUZLG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM148325![]() (US8962637, 137 | US8962637, 51) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent | Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J... | US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM148325![]() (US8962637, 137 | US8962637, 51) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent | Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J... | US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN | |||||||||||
More data for this Ligand-Target Pair |