BDBM148374 US8962637, 99

SMILES: Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)N3CCCC3)ncc2C1

InChI Key: InChIKey=ICDKRHFFALYPNE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM148374 (US8962637, 99) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)N3CCCC3)ncc2C1 Show InChI InChI=1S/C33H31F3N6O2/c1-21-7-10-27(38-30(43)23-5-4-6-25(17-23)33(34,35)36)18-29(21)42-16-13-28-24(20-42)19-37-32(40-28)39-26-11-8-22(9-12-26)31(44)41-14-2-3-15-41/h4-12,17-19H,2-3,13-16,20H2,1H3,(H,38,43)(H,37,39,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM148374 (US8962637, 99) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)N3CCCC3)ncc2C1 Show InChI InChI=1S/C33H31F3N6O2/c1-21-7-10-27(38-30(43)23-5-4-6-25(17-23)33(34,35)36)18-29(21)42-16-13-28-24(20-42)19-37-32(40-28)39-26-11-8-22(9-12-26)31(44)41-14-2-3-15-41/h4-12,17-19H,2-3,13-16,20H2,1H3,(H,38,43)(H,37,39,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
					More data for this Ligand-Target Pair