BDBM148382 US8962637, 107

SMILES: Cc1ccc(NC(=O)N2CCCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1

InChI Key: InChIKey=VOURYMYVBGIOOG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148382   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM148382 (US8962637, 107) Show SMILES Cc1ccc(NC(=O)N2CCCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1 Show InChI InChI=1S/C32H41N7O2/c1-24-7-8-27(35-32(40)38-16-3-2-4-17-38)21-30(24)39-18-13-29-25(23-39)22-33-31(36-29)34-26-9-11-28(12-10-26)41-20-19-37-14-5-6-15-37/h7-12,21-22H,2-6,13-20,23H2,1H3,(H,35,40)(H,33,34,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM148382 (US8962637, 107) Show SMILES Cc1ccc(NC(=O)N2CCCCC2)cc1N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1 Show InChI InChI=1S/C32H41N7O2/c1-24-7-8-27(35-32(40)38-16-3-2-4-17-38)21-30(24)39-18-13-29-25(23-39)22-33-31(36-29)34-26-9-11-28(12-10-26)41-20-19-37-14-5-6-15-37/h7-12,21-22H,2-6,13-20,23H2,1H3,(H,35,40)(H,33,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
					More data for this Ligand-Target Pair