BDBM148394 US8962637, 119
SMILES: Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(nc3)C(N)=O)ncc2C1
InChI Key: InChIKey=LXJDKJLDFQBOTM-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM148394![]() (US8962637, 119) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent | Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J... | US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN | |||||||||||
More data for this Ligand-Target Pair |