BDBM148424 US8962637, 155
SMILES: CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCCC4)cc3)ncc2C1)C(F)(F)F
InChI Key: InChIKey=CEINQDWSZHAZSK-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM148424 (US8962637, 155) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent | Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J... | US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM148424 (US8962637, 155) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent | Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J... | US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN | |||||||||||
More data for this Ligand-Target Pair |