BDBM148429 US8962637, 160

SMILES: CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCN(C)CC4)cc3)ncc2C1)C(F)(F)F

InChI Key: InChIKey=UZICUOYVCKOCLZ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148429   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM148429 (US8962637, 160) Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCN(C)CC4)cc3)ncc2C1)C(F)(F)F Show InChI InChI=1S/C32H40F3N7O2/c1-22-4-5-26(37-30(43)18-23(2)32(33,34)35)19-29(22)42-11-10-28-24(21-42)20-36-31(39-28)38-25-6-8-27(9-7-25)44-17-16-41-14-12-40(3)13-15-41/h4-9,19-20,23H,10-18,21H2,1-3H3,(H,37,43)(H,36,38,39)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM148429 (US8962637, 160) Show SMILES CC(CC(=O)Nc1ccc(C)c(c1)N1CCc2nc(Nc3ccc(OCCN4CCN(C)CC4)cc3)ncc2C1)C(F)(F)F Show InChI InChI=1S/C32H40F3N7O2/c1-22-4-5-26(37-30(43)18-23(2)32(33,34)35)19-29(22)42-11-10-28-24(21-42)20-36-31(39-28)38-25-6-8-27(9-7-25)44-17-16-41-14-12-40(3)13-15-41/h4-9,19-20,23H,10-18,21H2,1-3H3,(H,37,43)(H,36,38,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Debiopharm S.A.; Aurigene Discovery Technologies Ltd. US Patent					Assay Description Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...				US Patent US8962637 (2015) BindingDB Entry DOI: 10.7270/Q2MS3RGN
					More data for this Ligand-Target Pair