BindingDB PrimarySearch

BDBM150758 2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d)::US9271961, 2'-Hydroxyflavone

SMILES: Oc1ccccc1-c1cc(=O)c2ccccc2o1

InChI Key: InChIKey=ZZLQHXCRRMUGQJ-UHFFFAOYSA-N

Data: 2 KI 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 150758
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology					Assay Description The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...				Bioorg Chem 58: 72-80 (2015) Article DOI: 10.1016/j.bioorg.2014.11.008 BindingDB Entry DOI: 10.7270/Q2PG1QFJ
Birla Institute of Technology					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	5.98E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Birla Institute of Technology					Assay Description The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =...				Bioorg Chem 58: 72-80 (2015) Article DOI: 10.1016/j.bioorg.2014.11.008 BindingDB Entry DOI: 10.7270/Q2PG1QFJ
Birla Institute of Technology					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member C1 (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of the University of Pennsylvania US Patent					Assay Description Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...				US Patent US9271961 (2016) BindingDB Entry DOI: 10.7270/Q27W6B22
The Trustees of the University of Pennsylvania US Patent					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kanazawa University Curated by ChEMBL					Assay Description Antagonist activity at AR in human LNCAP cells assessed as reduction in DHT-induced cell growth treated for every 2 days for 4 days by hemocytometry				Eur J Med Chem 157: 1143-1152 (2018) Article DOI: 10.1016/j.ejmech.2018.08.069 BindingDB Entry DOI: 10.7270/Q24X5BHX
Kanazawa University Curated by ChEMBL					More data for this Ligand-Target Pair
Androgen Receptor (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kanazawa University Curated by ChEMBL					Assay Description Antagonist activity at AR in human LNCAP cells assessed as reduction in DHT-induced transcriptional activation after 24 hrs by luciferase reporter ge...				Eur J Med Chem 157: 1143-1152 (2018) Article DOI: 10.1016/j.ejmech.2018.08.069 BindingDB Entry DOI: 10.7270/Q24X5BHX
Kanazawa University Curated by ChEMBL					More data for this Ligand-Target Pair
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of the University of Pennsylvania US Patent					Assay Description Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...				US Patent US9271961 (2016) BindingDB Entry DOI: 10.7270/Q27W6B22
The Trustees of the University of Pennsylvania US Patent					More data for this Ligand-Target Pair
Aldo-keto reductase family 1 member C2 (Homo sapiens (Human))	BDBM150758 (2-(2-Hydroxyphenyl)-4H-chromen-4-one (3d) \| US9271...) Show SMILES Oc1ccccc1-c1cc(=O)c2ccccc2o1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.71E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of the University of Pennsylvania US Patent					Assay Description Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...				US Patent US9271961 (2016) BindingDB Entry DOI: 10.7270/Q27W6B22
The Trustees of the University of Pennsylvania US Patent					More data for this Ligand-Target Pair