BDBM150781 2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one (1d)
SMILES: COc1ccc(cc1)C1NC(=O)c2ccccc2N1
InChI Key: InChIKey=YYTAMNASXHFOKH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cathepsin B (Capra hircus (Goat)) | BDBM150781 (2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 2.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Kurukshetra University | Assay Description Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was... | Bioorg Chem 59: 12-22 (2015) Article DOI: 10.1016/j.bioorg.2015.01.005 BindingDB Entry DOI: 10.7270/Q2DZ071B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cathepsin H (Capra hircus (Goat)) | BDBM150781 (2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 5.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 6.0 | n/a |
Kurukshetra University | Assay Description Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 µL of the enzyme solution was... | Bioorg Chem 59: 12-22 (2015) Article DOI: 10.1016/j.bioorg.2015.01.005 BindingDB Entry DOI: 10.7270/Q2DZ071B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM150781 (2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assay | Bioorg Med Chem 23: 4139-49 (2015) Article DOI: 10.1016/j.bmc.2015.06.063 BindingDB Entry DOI: 10.7270/Q2W66NJ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Similar to alpha-tubulin isoform 1 (Bos taurus) | BDBM150781 (2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
China Medical College Curated by ChEMBL | Assay Description Inhibition of bovine tubulin polymerization | J Med Chem 43: 4479-87 (2000) Article DOI: 10.1021/jm000151c BindingDB Entry DOI: 10.7270/Q2JS9T53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM150781 (2-(4-Methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-on...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu Curated by ChEMBL | Assay Description Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assay | Bioorg Med Chem 23: 4139-49 (2015) Article DOI: 10.1016/j.bmc.2015.06.063 BindingDB Entry DOI: 10.7270/Q2W66NJ2 | |||||||||||
More data for this Ligand-Target Pair |