BDBM151745 US8987445, 181

SMILES: Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=OWRMBNVULAPTPT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 151745   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM151745 (US8987445, 181) Show SMILES Cc1c(nc(C2CC2)c2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C31H27ClF2N2O4S/c1-18-24-4-2-3-5-25(24)28(20-7-8-20)35-29(18)36(41(39,40)23-13-9-21(10-14-23)30(37)38)17-19-6-15-26(27(32)16-19)31(33,34)22-11-12-22/h2-6,9-10,13-16,20,22H,7-8,11-12,17H2,1H3,(H,37,38)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	37
Mitsubishi Tanabe Pharma Corporation US Patent					Assay Description The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...				US Patent US8987445 (2015) BindingDB Entry DOI: 10.7270/Q2BZ64R5
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