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SMILES: Cc1c(ncc2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=RWDVLHZFVUVTNK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 151765   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM151765
PNG
(US8987445, 201)
Show SMILES Cc1c(ncc2ccccc12)N(Cc1ccc(c(Cl)c1)C(F)(F)C1CC1)S(=O)(=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H23ClF2N2O4S/c1-17-23-5-3-2-4-20(23)15-32-26(17)33(38(36,37)22-11-7-19(8-12-22)27(34)35)16-18-6-13-24(25(29)14-18)28(30,31)21-9-10-21/h2-8,11-15,21H,9-10,16H2,1H3,(H,34,35)
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Similars
US Patent
n/an/a 0.600n/an/an/an/an/a37



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The functional activity of compounds was determined by measuring changes in intracellular calcium concentration using a Ca2+ sensitive fluorescent dy...

US Patent US8987445 (2015)


BindingDB Entry DOI: 10.7270/Q2BZ64R5
More data for this
Ligand-Target Pair