BDBM152991 US8993614, 11B
SMILES: COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(=O)O[C@H](C)OC(=O)N1CCOCC1
InChI Key: InChIKey=HSPLQOYQAJREPF-FXTFUQPHSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM152991 (US8993614, 11B) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19.4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche AG US Patent | Assay Description The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence... | US Patent US8993614 (2015) BindingDB Entry DOI: 10.7270/Q27W69XV | |||||||||||
More data for this Ligand-Target Pair |