BDBM153708 3-Phenyl-2-(4-((4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one (7g)

SMILES: O=C(C1CCCO1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1

InChI Key:

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153708   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) (Homo sapiens (Human))	BDBM153708 (3-Phenyl-2-(4-((4-(tetrahydrofuran-2-carbonyl)pipe...) Show SMILES O=C(C1CCCO1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1 Show InChI	PDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	8.00E+3	n/a	n/a	n/a	7.4	n/a
Technische Universität Dortmund					Assay Description Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...				ACS Chem Biol 10: 279-88 (2015) Article DOI: 10.1021/cb500355c BindingDB Entry DOI: 10.7270/Q218358G
					More data for this Ligand-Target Pair
Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) (Homo sapiens (Human))	BDBM153708 (3-Phenyl-2-(4-((4-(tetrahydrofuran-2-carbonyl)pipe...) Show SMILES O=C(C1CCCO1)N1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1 Show InChI	PDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universität Dortmund					Assay Description IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...				ACS Chem Biol 10: 279-88 (2015) Article DOI: 10.1021/cb500355c BindingDB Entry DOI: 10.7270/Q218358G
					More data for this Ligand-Target Pair