BDBM15554 (3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-fluorophenyl)methyl]-7-methyl-1,4-diazepan-2-one::7-methyl diazepanone 15e
SMILES: C[C@@H]1CCN([C@H](Cc2ccccc2F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
InChI Key: InChIKey=MJLIHCWJDFBSGU-NZCGUCNHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM15554![]() ((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.77 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 1903-7 (2007) Article DOI: 10.1016/j.bmcl.2007.01.039 BindingDB Entry DOI: 10.7270/Q2QZ2870 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM15554![]() ((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 1903-7 (2007) Article DOI: 10.1016/j.bmcl.2007.01.039 BindingDB Entry DOI: 10.7270/Q2QZ2870 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human)) | BDBM15554![]() ((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 1903-7 (2007) Article DOI: 10.1016/j.bmcl.2007.01.039 BindingDB Entry DOI: 10.7270/Q2QZ2870 | |||||||||||
More data for this Ligand-Target Pair |