null
SMILES: C[C@H]1N(CC[C@@H](NC1=O)C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
InChI Key: InChIKey=RHGCBYSUEYSEIU-PJCOJXEDSA-N
PDB links: 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM15556 ((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 1903-7 (2007) Article DOI: 10.1016/j.bmcl.2007.01.039 BindingDB Entry DOI: 10.7270/Q2QZ2870 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 8 (Homo sapiens (Human)) | BDBM15556 ((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 1903-7 (2007) Article DOI: 10.1016/j.bmcl.2007.01.039 BindingDB Entry DOI: 10.7270/Q2QZ2870 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 2 (Homo sapiens (Human)) | BDBM15556 ((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 1903-7 (2007) Article DOI: 10.1016/j.bmcl.2007.01.039 BindingDB Entry DOI: 10.7270/Q2QZ2870 | |||||||||||
More data for this Ligand-Target Pair |