BDBM156270 US9018217, [2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylsulfanylmethyl)-4-phenyl-imidazol-1-yl]-acetonitrile::US9592230, [2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylsulfanylmethyl)-4-phenyl-imidazol-1-yl]-acetonitrile
SMILES: Cc1cc(C)n2nc(SCc3nc(cn3CC#N)-c3ccccc3)nc2c1
InChI Key: InChIKey=YPAXEPKOHLYXDX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM156270 (US9018217, [2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme... | US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM156270 (US9018217, [2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | 25 |
H. Lundbeck A/S US Patent | Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme... | US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1 | |||||||||||
More data for this Ligand-Target Pair |