BDBM156383 US9018381, 6::US9248140, 6

SMILES: O[C@H](CF)CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=RIMLWEFZWHQOEH-KWYPLSMNSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 156383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM156383 (US9018381, 6 | US9248140, 6) Show SMILES O[C@H](CF)CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C49H54ClF4N5O7S3/c50-37-14-10-34(11-15-37)43-8-4-5-9-44(43)47(61)35-20-24-59(25-21-35)39-16-12-36(13-17-39)48(62)56-69(65,66)42-18-19-45(46(30-42)68(63,64)49(52,53)54)55-38(33-67-41-6-2-1-3-7-41)22-23-57-26-28-58(29-27-57)32-40(60)31-51/h1-19,30,35,38,40,47,55,60-61H,20-29,31-33H2,(H,56,62)/t38-,40-,47-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...				US Patent US9018381 (2015) BindingDB Entry DOI: 10.7270/Q2BC3X8D
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM156383 (US9018381, 6 | US9248140, 6) Show SMILES O[C@H](CF)CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C49H54ClF4N5O7S3/c50-37-14-10-34(11-15-37)43-8-4-5-9-44(43)47(61)35-20-24-59(25-21-35)39-16-12-36(13-17-39)48(62)56-69(65,66)42-18-19-45(46(30-42)68(63,64)49(52,53)54)55-38(33-67-41-6-2-1-3-7-41)22-23-57-26-28-58(29-27-57)32-40(60)31-51/h1-19,30,35,38,40,47,55,60-61H,20-29,31-33H2,(H,56,62)/t38-,40-,47-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...				US Patent US9248140 (2016) BindingDB Entry DOI: 10.7270/Q21G0K34
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-XL (Homo sapiens (Human))	BDBM156383 (US9018381, 6 | US9248140, 6) Show SMILES O[C@H](CF)CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C49H54ClF4N5O7S3/c50-37-14-10-34(11-15-37)43-8-4-5-9-44(43)47(61)35-20-24-59(25-21-35)39-16-12-36(13-17-39)48(62)56-69(65,66)42-18-19-45(46(30-42)68(63,64)49(52,53)54)55-38(33-67-41-6-2-1-3-7-41)22-23-57-26-28-58(29-27-57)32-40(60)31-51/h1-19,30,35,38,40,47,55,60-61H,20-29,31-33H2,(H,56,62)/t38-,40-,47-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...				US Patent US9248140 (2016) BindingDB Entry DOI: 10.7270/Q21G0K34
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM156383 (US9018381, 6 | US9248140, 6) Show SMILES O[C@H](CF)CN1CCN(CC[C@H](CSc2ccccc2)Nc2ccc(cc2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c2ccc(cc2)N2CCC(CC2)[C@@H](O)c2ccccc2-c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C49H54ClF4N5O7S3/c50-37-14-10-34(11-15-37)43-8-4-5-9-44(43)47(61)35-20-24-59(25-21-35)39-16-12-36(13-17-39)48(62)56-69(65,66)42-18-19-45(46(30-42)68(63,64)49(52,53)54)55-38(33-67-41-6-2-1-3-7-41)22-23-57-26-28-58(29-27-57)32-40(60)31-51/h1-19,30,35,38,40,47,55,60-61H,20-29,31-33H2,(H,56,62)/t38-,40-,47-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...				US Patent US9018381 (2015) BindingDB Entry DOI: 10.7270/Q2BC3X8D
					More data for this Ligand-Target Pair