BDBM156388 US9018381, 11::US9248140, 11

SMILES: CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](N)c1ccccc1-c1ccc(Cl)cc1

InChI Key: InChIKey=NMQFUMLYFHPROZ-UJNHCCGESA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 156388   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM156388 (US9018381, 11 | US9248140, 11) Show SMILES CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](N)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H49ClF3N5O6S3/c1-53(27-28-55)24-23-35(30-61-37-7-3-2-4-8-37)51-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)52-44(56)33-13-17-36(18-14-33)54-25-21-32(22-26-54)43(50)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,51,55H,21-28,30,50H2,1H3,(H,52,56)/t35-,43-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...				US Patent US9018381 (2015) BindingDB Entry DOI: 10.7270/Q2BC3X8D
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM156388 (US9018381, 11 | US9248140, 11) Show SMILES CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](N)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H49ClF3N5O6S3/c1-53(27-28-55)24-23-35(30-61-37-7-3-2-4-8-37)51-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)52-44(56)33-13-17-36(18-14-33)54-25-21-32(22-26-54)43(50)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,51,55H,21-28,30,50H2,1H3,(H,52,56)/t35-,43-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...				US Patent US9248140 (2016) BindingDB Entry DOI: 10.7270/Q21G0K34
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-XL (Homo sapiens (Human))	BDBM156388 (US9018381, 11 | US9248140, 11) Show SMILES CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](N)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H49ClF3N5O6S3/c1-53(27-28-55)24-23-35(30-61-37-7-3-2-4-8-37)51-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)52-44(56)33-13-17-36(18-14-33)54-25-21-32(22-26-54)43(50)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,51,55H,21-28,30,50H2,1H3,(H,52,56)/t35-,43-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...				US Patent US9248140 (2016) BindingDB Entry DOI: 10.7270/Q21G0K34
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM156388 (US9018381, 11 | US9248140, 11) Show SMILES CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](N)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H49ClF3N5O6S3/c1-53(27-28-55)24-23-35(30-61-37-7-3-2-4-8-37)51-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)52-44(56)33-13-17-36(18-14-33)54-25-21-32(22-26-54)43(50)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,51,55H,21-28,30,50H2,1H3,(H,52,56)/t35-,43-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...				US Patent US9018381 (2015) BindingDB Entry DOI: 10.7270/Q2BC3X8D
					More data for this Ligand-Target Pair