BDBM156393 US9018381, 16::US9248140, 16

SMILES: O[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O)c1ccccc1-c1ccc(Cl)cc1

InChI Key: InChIKey=STNWTWVPOINSDM-CAZXVXRPSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 156393   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM156393 (US9018381, 16 | US9248140, 16) Show SMILES O[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H48ClN5O7S2/c46-35-14-10-32(11-15-35)40-8-4-5-9-41(40)44(52)33-20-24-50(25-21-33)37-16-12-34(13-17-37)45(53)48-60(56,57)39-18-19-42(43(30-39)51(54)55)47-36(22-23-49-26-28-58-29-27-49)31-59-38-6-2-1-3-7-38/h1-19,30,33,36,44,47,52H,20-29,31H2,(H,48,53)/t36-,44-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...				US Patent US9018381 (2015) BindingDB Entry DOI: 10.7270/Q2BC3X8D
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM156393 (US9018381, 16 | US9248140, 16) Show SMILES O[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H48ClN5O7S2/c46-35-14-10-32(11-15-35)40-8-4-5-9-41(40)44(52)33-20-24-50(25-21-33)37-16-12-34(13-17-37)45(53)48-60(56,57)39-18-19-42(43(30-39)51(54)55)47-36(22-23-49-26-28-58-29-27-49)31-59-38-6-2-1-3-7-38/h1-19,30,33,36,44,47,52H,20-29,31H2,(H,48,53)/t36-,44-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...				US Patent US9248140 (2016) BindingDB Entry DOI: 10.7270/Q21G0K34
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-XL (Homo sapiens (Human))	BDBM156393 (US9018381, 16 | US9248140, 16) Show SMILES O[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H48ClN5O7S2/c46-35-14-10-32(11-15-35)40-8-4-5-9-41(40)44(52)33-20-24-50(25-21-33)37-16-12-34(13-17-37)45(53)48-60(56,57)39-18-19-42(43(30-39)51(54)55)47-36(22-23-49-26-28-58-29-27-49)31-59-38-6-2-1-3-7-38/h1-19,30,33,36,44,47,52H,20-29,31H2,(H,48,53)/t36-,44-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-c) may be determined using a variety of kno...				US Patent US9248140 (2016) BindingDB Entry DOI: 10.7270/Q21G0K34
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM156393 (US9018381, 16 | US9248140, 16) Show SMILES O[C@H](C1CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O)c1ccccc1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C45H48ClN5O7S2/c46-35-14-10-32(11-15-35)40-8-4-5-9-41(40)44(52)33-20-24-50(25-21-33)37-16-12-34(13-17-37)45(53)48-60(56,57)39-18-19-42(43(30-39)51(54)55)47-36(22-23-49-26-28-58-29-27-49)31-59-38-6-2-1-3-7-38/h1-19,30,33,36,44,47,52H,20-29,31H2,(H,48,53)/t36-,44-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...				US Patent US9018381 (2015) BindingDB Entry DOI: 10.7270/Q2BC3X8D
					More data for this Ligand-Target Pair