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SMILES: Cc1ncc2c(nn(Cc3ccccc3F)c2n1)-c1ncc2c(NC(=O)C2(C)C)n1

InChI Key: InChIKey=MBKLBCXLSHOXAI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157145   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM157145
PNG
(US9023849, 15)
Show SMILES Cc1ncc2c(nn(Cc3ccccc3F)c2n1)-c1ncc2c(NC(=O)C2(C)C)n1
Show InChI InChI=1S/C21H18FN7O/c1-11-23-8-13-16(18-24-9-14-17(26-18)27-20(30)21(14,2)3)28-29(19(13)25-11)10-12-6-4-5-7-15(12)22/h4-9H,10H2,1-3H3,(H,24,26,27,30)
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Similars
US Patent
n/an/a 310n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9023849 (2015)


BindingDB Entry DOI: 10.7270/Q2TD9W3Q
More data for this
Ligand-Target Pair