BDBM157148 US9023849, 18

SMILES: Cc1ncc2c(nn(Cc3cccc(F)c3F)c2n1)-c1nnc2c(NC(=O)C2(C)C)n1

InChI Key: InChIKey=WDJLWIIPYSERLC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM157148 (US9023849, 18) Show SMILES Cc1ncc2c(nn(Cc3cccc(F)c3F)c2n1)-c1nnc2c(NC(=O)C2(C)C)n1 Show InChI InChI=1S/C20H16F2N8O/c1-9-23-7-11-14(16-25-17-15(27-28-16)20(2,3)19(31)26-17)29-30(18(11)24-9)8-10-5-4-6-12(21)13(10)22/h4-7H,8H2,1-3H3,(H,25,26,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9023849 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W3Q
					More data for this Ligand-Target Pair