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SMILES: CCc1nc(nc2NC(=O)C(C)(C)c12)-n1nc(Cc2ccccc2F)c2cc(F)ccc12

InChI Key: InChIKey=YDGCOUPUQARPIJ-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 157152   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM157152
PNG
(US9023849, 23)
Show SMILES CCc1nc(nc2NC(=O)C(C)(C)c12)-n1nc(Cc2ccccc2F)c2cc(F)ccc12
Show InChI InChI=1S/C24H21F2N5O/c1-4-17-20-21(28-22(32)24(20,2)3)29-23(27-17)31-19-10-9-14(25)12-15(19)18(30-31)11-13-7-5-6-8-16(13)26/h5-10,12H,4,11H2,1-3H3,(H,27,28,29,32)
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Similars
US Patent
n/an/a 440n/an/an/an/a7.5n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...

US Patent US9023849 (2015)


BindingDB Entry DOI: 10.7270/Q2TD9W3Q
More data for this
Ligand-Target Pair