null

SMILES: CN(C)C(=O)C(C)(O)C#Cc1cc2-c3nc(cn3CCOc2cc1F)C(N)=O

InChI Key: InChIKey=VJSBIVNVMGEWDN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 158576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM158576 (US9034866, 51) Show SMILES CN(C)C(=O)C(C)(O)C#Cc1cc2-c3nc(cn3CCOc2cc1F)C(N)=O Show InChI InChI=1S/C19H19FN4O4/c1-19(27,18(26)23(2)3)5-4-11-8-12-15(9-13(11)20)28-7-6-24-10-14(16(21)25)22-17(12)24/h8-10,27H,6-7H2,1-3H3,(H2,21,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	721	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...				US Patent US9034866 (2015) BindingDB Entry DOI: 10.7270/Q2GX49B0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM158576 (US9034866, 51) Show SMILES CN(C)C(=O)C(C)(O)C#Cc1cc2-c3nc(cn3CCOc2cc1F)C(N)=O Show InChI InChI=1S/C19H19FN4O4/c1-19(27,18(26)23(2)3)5-4-11-8-12-15(9-13(11)20)28-7-6-24-10-14(16(21)25)22-17(12)24/h8-10,27H,6-7H2,1-3H3,(H2,21,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	986	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of NIK (unknown origin) after 1 to 2 hrs by ADP-FP assay				J Med Chem 60: 627-640 (2017) Article DOI: 10.1021/acs.jmedchem.6b01363 BindingDB Entry DOI: 10.7270/Q2K35X4S
					More data for this Ligand-Target Pair