BDBM160509 US10280160, Example 1.::US9682969, 1

SMILES: CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1

InChI Key: InChIKey=RMNQRSAGJVUIBD-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 160509   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480] (Homo sapiens (Human))	BDBM160509 (US10280160, Example 1. | US9682969, 1) Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1 Show InChI InChI=1S/C25H19ClN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Flatley Discovery Lab, LLC US Patent					Assay Description This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...				US Patent US9682969 (2017) BindingDB Entry DOI: 10.7270/Q2SQ8XKT
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM160509 (US10280160, Example 1. | US9682969, 1) Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1 Show InChI InChI=1S/C25H19ClN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Y. B. Chavan College of Pharmacy Curated by ChEMBL					Assay Description Inhibition of human CFTR F508 deletion mutant expressed in rat FRT cells coexpressing YFP-H148Q/I152L 25,22 incubated for 60 to 120 mins in presence ...				Bioorg Med Chem 27: 3979-3997 (2019) Article DOI: 10.1016/j.bmc.2019.07.050
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM160509 (US10280160, Example 1. | US9682969, 1) Show SMILES CN(C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccccc2c1=O)c1ccc2nc(C)oc2c1 Show InChI InChI=1S/C25H19ClN4O3/c1-15-27-21-11-10-18(13-22(21)33-15)29(2)23(31)14-30-25(32)20-9-4-3-8-19(20)24(28-30)16-6-5-7-17(26)12-16/h3-13H,14H2,1-2H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...				Proc Natl Acad Sci U S A 105: 3041-6 (2008) BindingDB Entry DOI: 10.7270/Q2M047SX
					More data for this Ligand-Target Pair