BDBM160512 US10280160, Example 6.::US9682969, 4::US9682969, 6
SMILES: COc1ccc2c(nn(CC(=O)N(C)c3ccc4nc(C)oc4c3)c(=O)c2c1)-c1cccc(Cl)c1
InChI Key: InChIKey=LKTPKALWKRJARY-UHFFFAOYSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CFTR F508del (Homo sapiens (Human)) | BDBM160512 (US10280160, Example 6. | US9682969, 4 | US9682969,...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a |
Flatley Discovery Lab, LLC US Patent | Assay Description This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein... | US Patent US9682969 (2017) BindingDB Entry DOI: 10.7270/Q2SQ8XKT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM160512 (US10280160, Example 6. | US9682969, 4 | US9682969,...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G... | Proc Natl Acad Sci U S A 105: 3041-6 (2008) BindingDB Entry DOI: 10.7270/Q2M047SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human)) | BDBM160512 (US10280160, Example 6. | US9682969, 4 | US9682969,...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G... | Proc Natl Acad Sci U S A 105: 3041-6 (2008) BindingDB Entry DOI: 10.7270/Q2M047SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CFTR F508del (Homo sapiens (Human)) | BDBM160512 (US10280160, Example 6. | US9682969, 4 | US9682969,...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a |
Flatley Discovery Lab, LLC US Patent | Assay Description This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein... | US Patent US9682969 (2017) BindingDB Entry DOI: 10.7270/Q2SQ8XKT | |||||||||||
More data for this Ligand-Target Pair |