BDBM160523 US10280160, Example 15.::US9682969, 15

SMILES: Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O

InChI Key: InChIKey=TVHQFJMUNNVMTG-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 160523   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM160523 (US10280160, Example 15. | US9682969, 15) Show SMILES Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O Show InChI InChI=1S/C27H21ClN4O4/c1-15-29-23-10-7-19(12-24(23)36-15)32(18-5-6-18)25(34)14-31-27(35)22-13-20(33)8-9-21(22)26(30-31)16-3-2-4-17(28)11-16/h2-4,7-13,18,33H,5-6,14H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Plexxikon					Assay Description Fisher Rat Thyroid (FRT) cells stably expressing both human F508del CFTR and a halide-sensitive yellow fluorescent protein (YFP-H148Q/I152L 25,22) (G...				Proc Natl Acad Sci U S A 105: 3041-6 (2008) BindingDB Entry DOI: 10.7270/Q2M047SX
					More data for this Ligand-Target Pair
CFTR F508del (Homo sapiens (Human))	BDBM160523 (US10280160, Example 15. | US9682969, 15) Show SMILES Cc1nc2ccc(cc2o1)N(C1CC1)C(=O)Cn1nc(-c2cccc(Cl)c2)c2ccc(O)cc2c1=O Show InChI InChI=1S/C27H21ClN4O4/c1-15-29-23-10-7-19(12-24(23)36-15)32(18-5-6-18)25(34)14-31-27(35)22-13-20(33)8-9-21(22)26(30-31)16-3-2-4-17(28)11-16/h2-4,7-13,18,33H,5-6,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Flatley Discovery Lab, LLC US Patent					Assay Description This protocol is designed to selectively screen small molecule compounds for F508del CFTR corrector activities in the YFP (yellow fluorescent protein...				US Patent US9682969 (2017) BindingDB Entry DOI: 10.7270/Q2SQ8XKT
					More data for this Ligand-Target Pair