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SMILES: Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNc1ccc(cn1)[N+]#[C-]

InChI Key: InChIKey=GEEMYPXYKAFEDX-FZCLLLDFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 161043   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens (Human))		BDBM161043
PNG
(US9108947, 18)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNc1ccc(cn1)[N+]#[C-] |r|
Show InChI InChI=1S/C22H24N4O3/c1-14-17(6-7-18-19(14)13-29-22(18)28)20(27)12-26-9-3-4-16(26)11-25-21-8-5-15(23-2)10-24-21/h5-8,10,16,20,27H,3-4,9,11-13H2,1H3,(H,24,25)/t16?,20-/m0/s1
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Similars
US Patent
n/an/a 65n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...

US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair