BDBM162323 US10307427, Compound 14::US9051313, 14

SMILES: C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)(O)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F

InChI Key: InChIKey=MQGKAHLKCUKYGG-HNNXBMFYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 162323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM162323 (US10307427, Compound 14 | US9051313, 14) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)(O)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N9O2S/c1-15(26(27,28)29)38-14-32-35-22(38)24-34-21(12-41-24)33-23(39)17-9-19(37-11-18(31-13-37)16-3-4-16)20(10-30-17)36-7-5-25(2,40)6-8-36/h9-16,40H,3-8H2,1-2H3,(H,33,39)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Washington University					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...				J Med Chem 52: 2188-91 (2009) BindingDB Entry DOI: 10.7270/Q2K64MD9
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human))	BDBM162323 (US10307427, Compound 14 | US9051313, 14) Show SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCC(C)(O)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F |r| Show InChI InChI=1S/C26H28F3N9O2S/c1-15(26(27,28)29)38-14-32-35-22(38)24-34-21(12-41-24)33-23(39)17-9-19(37-11-18(31-13-37)16-3-4-16)20(10-30-17)36-7-5-25(2,40)6-8-36/h9-16,40H,3-8H2,1-2H3,(H,33,39)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Gildead Sciences, Inc. US Patent					Assay Description The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...				US Patent US9051313 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZVX
					More data for this Ligand-Target Pair