BDBM163718 3-(2-Chlorophenyl)-5-{4-[4-(2-fluorophenyl)piperazin-1-yl]butyl}-4,5-dihydro-1,2,4-triazin-6(1H)-one (17)

SMILES: Fc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)c2ccccc2Cl)CC1

InChI Key: InChIKey=UWSHTUMQHVLLPC-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163718   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM163718 (3-(2-Chlorophenyl)-5-{4-[4-(2-fluorophenyl)piperaz...) Show SMILES Fc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)c2ccccc2Cl)CC1 |c:18| Show InChI InChI=1S/C23H27ClFN5O/c24-18-8-2-1-7-17(18)22-26-20(23(31)28-27-22)10-5-6-12-29-13-15-30(16-14-29)21-11-4-3-9-19(21)25/h1-4,7-9,11,20H,5-6,10,12-16H2,(H,26,27)(H,28,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	37	-10.1	n/a	n/a	n/a	n/a	n/a	n/a	25
Jagiellonian University Medical College					Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...				Chem Biol Drug Des 86: 697-703 (2015) Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM163718 (3-(2-Chlorophenyl)-5-{4-[4-(2-fluorophenyl)piperaz...) Show SMILES Fc1ccccc1N1CCN(CCCCC2NC(=NNC2=O)c2ccccc2Cl)CC1 |c:18| Show InChI InChI=1S/C23H27ClFN5O/c24-18-8-2-1-7-17(18)22-26-20(23(31)28-27-22)10-5-6-12-29-13-15-30(16-14-29)21-11-4-3-9-19(21)25/h1-4,7-9,11,20H,5-6,10,12-16H2,(H,26,27)(H,28,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	91	-9.60	n/a	n/a	n/a	n/a	n/a	n/a	25
Jagiellonian University Medical College					Assay Description All assays were incubated in a total volume of 200 mL in 96-well microtiter plates for 1 h at 37 °C, except for 5-HT1ARs which were incubated at room...				Chem Biol Drug Des 86: 697-703 (2015) Article DOI: 10.1111/cbdd.12539 BindingDB Entry DOI: 10.7270/Q2DR2T86
					More data for this Ligand-Target Pair